alzheimer's disease (ad), the most ordinary form of dementia and extracellular accumulation of amyloid-β (aβ) in senile plaques, is an important and a main event in the pathogenesis of ad. deposition of aβ peptide initiates a spectrum of cellular responses that are interposed by the resident neuroimmune cells of the brain, the microglia. recently, a novel inflammasome signaling  pathway ha...

Background: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. Objective: To investigate w...

Alzheimer's disease (AD), the most ordinary form of dementia and extracellular accumulation of Amyloid-β (Aβ) in senile plaques, is an important and a main event in the pathogenesis of AD. Deposition of Aβ Peptide initiates a spectrum of cellular responses that are interposed by the resident neuroimmune cells of the brain, the microglia. Recently, a novel inflammasome signaling&n...

The release of cytochrome c from the inner mitochondrial membrane, where it is anchored by caridolipin, triggers the formation of the Apaf-1 apoptosome. Cardiolipin also interacts with NLRP3 recruiting NLRP3 to mitochondria and facilitating inflammasome assembly. In this study we investigated whether cytosolic cytochrome c impacts NLRP3 inflammasome activation in macrophages. We report that cyt...

NLRP3 inflammasome has emerged as a key regulator of glucose and insulin homeostasis. Several studies have shown that activation of the NLRP3 inflammasome contributes to obesityinduced inflammation and insulin resistance [1]. Increased oxidative stress may also contribute to NLRP3 inflammasome activation during diabetes and its complications [2]. The NLRP3 inflammasome is a complexe that consis...

The NLRP3 inflammasome has a fundamental role in host defence against microbial pathogens and its deregulation may cause diverse inflammatory diseases. NLRP3 protein expression is a rate-limiting step for inflammasome activation, thus its expression must be tightly controlled to maintain immune homeostasis and avoid detrimental effects. However, how NLRP3 expression is regulated remains largely...

BACKGROUND NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response. However, the roles of NLRP3 inflammasome in the tumorigenesis and development of cancer stem cells (CSCs) of squamous cell carcinoma of the head and neck (SCCHN) remain ambiguous. METHODS In our study, tissue microarrays, ELISA, sphere-forming assay, colony formation assay and...

il-1β and il-17a are two cytokines with strong proinflammatory activities and are now known to be involved in a number of chronic inflammatory disorders. high-mobility group box 1 (hmgb1) is a nuclear protein regulating the expression of these proinflammatory cytokines. the nlrp3 inflammasome promotes the maturation of the il-1β and its activation has been shown as a critical mechanism in the p...

The NLRP3 inflammasome plays a major role in innate immune responses by activating caspase-1, resulting in secretion of IL-1β and inflammatory pathologic responses. Viral RNA can induce NLRP3 inflammasome activation. However, none of the components of NLRP3 inflammasome has the ability to bind viral RNA. Therefore, it had been proposed that there might have been some unidentified cytosolic RNA ...

Celastrol exhibits potential anti-inflammatory activity in a variety of inflammatory diseases, but the mechanism remains poorly understood. Activation of NLRP3 inflammasome is involved in multiple inflammatory diseases. Here, we show that celastrol abolishes the NLRP3 inflammasome activation, inhibits subsequent caspase-1 activation and IL-1β secretion both in vitro and in vivo. Notably, interr...